This variant, predicted to affect nonsense-mediated decay, has been associated with Parkinson (Nalls et al., 2014; Heckman et al., 2017) and TMEM175 deficiency is linked to the increase of α-synuclein aggregation (Jinn et al., 2017), suggesting a possible causal link. This evidence concerns the gene TMEM175 and Parkinsonism.