CHIP was found to be associated with an increased risk for coronary artery disease (CAD) by two-fold and premature MI by fourfold in the general population independently of age or other traditional cardiovascular risk factors (Jaiswal et al., 2017; Libby et al., 2019; Evans et al., 2020; Min et al., 2020). The gene discussed is STUB1; the disease is coronary artery disorder.