NOS1 and Alzheimer disease: Besides, an enormous number of more than 200 clinical disorders, including type 2 diabetes mellitus (T2DM), degenerative brain impairments like Alzheimer’s disease (AD) and Parkinson’s disease (PD), cardiovascular dysfunction, and cancer, have been associated with early dysregulations in redox homeostasis through so-called ROS and NOS (Kaul et al., 2001; Farah et al., 2018).