Polymorphisms in involved proteins such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were associated with various human metabolic disorders such as diabetes, CVD, and cancer (Crawford et al., 2012; Hebert-Schuster et al., 2012), emphasizing the critical role of enzymatic antioxidant systems. The gene discussed is CAT; the disease is metabolic disease.