T2-FLAIR mismatch sign (Figure 3), homogenously T2 hyperintense tumor with central hypointensity on FLAIR, can reliably predict IDH mutated 1p/19q non-co-deleted GBMs.40,41 On the other hand, high ITSS score on SWI is associated with IDH wildtype and MGMT unmethylated GBMs.42 The gene discussed is MGMT; the disease is neoplasm.