Endersby et al demonstrated the erythroblastic leukemia viral oncogene homolog inhibitor (pan-ERBB inhibitor) Dacomitinib inhibited EGFR signaling in in vitro models of pineoblastoma and had efficacy in orthotopic models of pediatric brain tumors.12 Many EGFR inhibitors have been tested in children. The gene discussed is EGFR; the disease is pineoblastoma.