However, the association between MTHFR CT genotype and arterial and venous thrombotic diseases as well as myocardial infarction (MI), ischemic stroke (IS), and peripheral vascular disease (PVD), is still under debate because of contrasting results [6–9], and because folate and vitamin B12 administration-related Hcy decrease does not significantly reduce major vascular event recurrence [10, 11]. This evidence concerns the gene MTHFR and myocardial infarction.