Molecular changes in AD encompass formation and accumulation of pathological structures in the brain, namely extracellular senile plaques containing aggregates of amyloid β peptide (Aβ) and intracellular neurofibrillary tangles consisting of hyperphosphorylated tau protein (Saido 2013; Sengoku 2020). The gene discussed is MAPT; the disease is Alzheimer disease.