Likewise, increased levels of CCL2 were found in brains of aged mice representing other Tg lines, such as Tg2576, 3xTg AD, and APP/PS1 (Hartlage-Rübsamen et al. 2015; Reale et al. 2018; Zaheer et al. 2013). This evidence concerns the gene PSEN1 and Alzheimer disease.