We identified a significant decrease in Cx-43 + junctions in the presence of LV-proximal GBM compared to other groups (mean ± SEM Vehicle: 40,132 ± 2287 Cx-43 + junctions/mm2 SVZ, LV-distal GBM: 46,053 ± 2029 Cx-43 + junctions/mm2 SVZ, LV-proximal GBM: 28,036 ± 3347 Cx-43 + junctions/mm2 SVZ, p < 0.05; Fig. 5A, B). Here, GJA1 is linked to glioblastoma.