Higher recent CD4 counts (200-499cells/mm3) (AOR = 3.15, 95%CI = 1.04–9.49) and (≥ 500 cells/mm3) (AOR = 7.58, 95%CI = 2.49–23.08), hypertension (AOR = 2.57, 95%CI = 1.24–5.35), higher baseline BMI status (AOR = 5.93, 95%CI = 2.62–13.40) and abdominal obesity (AOR = 1.82, 95%CI = 1.07–3.10) were significantly associated with overweight and obesity. The gene discussed is CD4; the disease is Obesity.