In breast cancer cells, lysine(K)-specific demethylase 6B and PI3K/AKT were able to promote IGFBP5 expression by suppressing EZH2-mediated histone three lysine 27 tri-methylation at the IGFBP5 promoter [75].These studies suggest a possible link between epigenetic silencing of IGFBP-5 and regulation of signaling pathways. This evidence concerns the gene IGFBP5 and breast carcinoma.