After multiple imputation of missing data in PS, WBC at diagnosis, and secondary vs de novo AML, all the chosen predictors (age, performance status, WBC at diagnosis, secondary vs de novo AML, cytogenetic risk, and NPM1/FLT3-ITD mutations) were included in a multivariate Cox proportional hazard model that predicts OS (Table 1). The gene discussed is NPM1; the disease is acute myeloid leukemia.