To examine the relevance of our findings in human malaria parasite, we assessed the ability of griseofulvin to inhibit Hz formation in Pf3D7 laboratory strain, artemisinin-resistant Pf clinical isolate from Cambodia (PfCam), multidrug-resistant Pf clinical isolate from Thailand (PfK1) and three Pf clinical isolates that were collected from India (PfI-1, −2 and −3). This evidence concerns the gene PFKM and malaria.