In the DLPFC of BD, subjecting the protein expression changes to GOplot we observed multiple downregulated key proteins including, MYH9, PDCD6IP, DBN1 and DBNL (Fig. 4A), which were clustered in at least two out of six GO terms of tissue remodeling, and downregulated key proteins including DBN1, ITGB1, ARHGEF7 and DBNL, which were clustered in at least two out of 7 GO terms of neuronal projection, and were hub proteins in the protein network (Fig. 4B, Supplementary Fig. 5). This evidence concerns the gene ITGB1 and Behcet disease.