We observed multiple downregulated key proteins of energy metabolism in the DLPFC of MDD, including PFKP, OGDH, SDHA, NDUFA10 and COX5B, which were clustered in at least two energy metabolism functions and were also hub proteins in the protein network (Fig. 2A, Supplementary Fig. 3). The gene discussed is COX5B; the disease is major depressive disorder.