It is also of interest to note that, although the tissue remodeling functional clusters were found to be both suppressed in both the ACC of MDD and the DLPFC of BD, the significantly changed proteins involved were different, except for an overlap of only four proteins, i.e., CORO2B, KIF5B, PDCD6IP and RDX. The gene discussed is PDCD6IP; the disease is major depressive disorder.