Our proteomic data covered more than 3000 proteins and identified more than 100 significantly different proteins as compared to controls, including OGDH, SDHA and COX5B in the DLPFC of MDD patients; PFN1, HSP90AA1 and PDCD6IP in the ACC of MDD patients; DBN1, DBNL and MYH9 in the DLPFC of BD patients. This evidence concerns the gene PFN1 and major depressive disorder.