It is also of interest to note that, although the tissue remodeling functional clusters were found to be both suppressed in both the ACC of MDD and the DLPFC of BD, the significantly changed proteins involved were different, except for an overlap of only four proteins, i.e., CORO2B, KIF5B, PDCD6IP and RDX. This evidence concerns the gene PDCD6IP and Behcet disease.