Each cluster contains distinct subsets of complement pathway (CP) genes, as well as distinct subsets of astrocyte-associated (Ast) [19], Arc microglia-associated (Arc Mic) [18], and AD-associated genes elevated in the 5xFAD mouse model with pathology (5xFAD up) [36] (Fig. 2C and Additional file 1: Fig S5B, C). The gene discussed is ARC; the disease is Alzheimer disease.