Twenty-four hours after administration, APG-2449 exerted dose-dependent suppression of tumor phosphorylated ALK (p-ALK), Ak strain transforming (p-AKT), extracellular signal-regulated kinase (p-ERK1/2), and signal transducer and activator of transcription (p-STAT3; Fig. 2E). This evidence concerns the gene MAPK3 and neoplasm.