A COPD correlation network was found that had three modules: one contained up-regulated switch genes associated with the control of immune and inflammatory responses as well as hypoxia including BLNK, HIF1A, LY96, PRDX4, SYK and TIMP1; one containing up-regulated immune genes and another containing reduced expression of the genome-wide association study (GWAS)-identified genes AGER and CAVIN1 in COPD cases [37]. Here, SYK is linked to chronic obstructive pulmonary disease.