Meta-analysis of the transcriptomic profiles of macrophage models stimulated for various times by LPS, LPS and interferon-γ, IFNγ, IL-4, IL-10 or dexamethasone identified alveolar macrophages as having a high similarity to IL-10 activated cells with a reduced enrichment of the IFNγ-stimulated macrophage gene signature in COPD [69]. The gene discussed is IL10; the disease is chronic obstructive pulmonary disease.