Although we could not rule out the other explanations for attenuated lung fibrosis in the absence of BRAP because hundreds of potential interacting partners with BRAP were revealed by the yeast two-hybrid screen, the findings of this study demonstrated that the physical interaction between BRAP and ATG5 is of particular interest in regulating cellular events and thus suggest a potential novel intracellular mechanism for regulating autophagy by BRAP. This evidence concerns the gene BRAP and pulmonary fibrosis.