PVT1 and ovarian cancer: Because serous ovarian cancers are marked by genome amplification (The Cancer Genome Atlas Research Network et al, 2011), we evaluated the effect of PVT1 amplification on PVT1 expression, by comparing PVT1 amplification versus expression and found that amplification and expression were highly correlated in ovarian cancer patients (Pearson factor of 0.46 P = 4.27 × 10−17, Fig 1F).