To test whether UTX was able to interact with MiDAC outside of the MLL3/4 complexes, we used HCT116 colorectal carcinoma cells which contain a homozygous frameshift mutation in MLL3 (MLL3−/− MLL4+/+) (Watanabe et al, 2011). The gene discussed is KMT2D; the disease is colorectal carcinoma.