LEP and cancer: Postmenopausal women are at a higher risk of developing cancer and cardiometabolic diseases, and one of the influencing factors, in addition to lifestyle parameters (such as physical inactivity, unhealthy eating habits), is the reduction in the levels of estrogen, which is characteristic of menopause that can cause changes in energy expenditure and reduced leptin sensitivity.31Estrogen is involved in the regulation of several physiological processes, and has receptors (α and β) in different organs and tissues.