AGT and diabetic kidney disease: One report has shown a significant graded inverse association between baseline serum total bilirubin levels and the progression of diabetic nephropathy in post hoc analysis in the Reduction of Endpoints in Non-Insulin Dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL) trial and in the Irbesartan Diabetic Nephropathy Trial (IDNT) [15].