Various mechanisms had been postulated for hyperglycemia in patients with FCPD, which include beta cell loss [5, 6], insulin secretory dysfunction [7, 8], receptor and signal transduction defects leading to insulin resistance [9, 10], and reduced incretin effect [11, 12], with the latter being linked to pancreatic exocrine insufficiency [13]. The gene discussed is INS; the disease is Hyperglycemia.