We found that site 8 was co-occupied by H3K27ac and H3K4me3 in all cells we studied, indicating that among 3 RASGRP2 promoters, TSS1 was active in lung cancer cells and that although RASGRP2 transcription activity was lower in A549 and H460 cells than in H1155 and H526 cells, its promoter was still in an active state. The gene discussed is RASGRP2; the disease is lung carcinoma.