GFI1 and lung cancer: Consistently, analysis of single-cell RNA-Seq data sets of human lung cancers generated by Rudin and colleagues (19) also revealed higher expression of GFI1 in SCLCs than in NSCLCs: all 4 primary SCLCs contained GFI1-expressing cancer cells, whereas only 8 out of 14 primary NSCLCs contained GFI1-expressing cancer cells (Supplemental Figure 1A).