The presence of enriched INS/GCG double-positive cells in a subpopulation of ductal cells in the experimental models that is not detected in the grafts in control nonpregnant NSG-Lox mice suggests that the differentiation of ductal cells to β-like cells occurs via an intermediate α-like cell during the adaptive response to overt insulin resistance and is consistent with ducts and islets sharing developmental origins (38). The gene discussed is GCG; the disease is Insulin resistance.