To determine the similarities in terms of global gene expression between insulin-resistant β cells and ductal clusters subjected to high insulin demand, we intersected the differentially regulated genes in T2D versus CTRL β cells from the GSE81608 public data set with the differentially regulated genes in ductal cluster 2 and cluster 4 in each of the 3 experimental models from the snRNA-Seq outputs (Figure 5C). The gene discussed is INS; the disease is type 2 diabetes mellitus.