INS and Impaired glucose tolerance: In particular, (a) SNPs found in the SCLY genetic locus were associated with insulin resistance in individuals of Mexican-American descent (50); (b) the whole body SCLY-KO mouse model manifested impaired glucose tolerance and metabolic syndrome (51), and such a phenotype was worsened upon challenge with high-fat diet (52); and (c) selenium increased insulin expression and secretion in mouse β cell lines (MIN6 cells) and rat pancreatic islets (53).