Thus, based on the close relationship between intestinal permeability and mortality in sepsis, we next determined whether deleting JAM-A specifically in the intestinal epithelium was responsible for the mortality benefit seen in KO mice, given that mice with enterocyte-specific deletion of JAM-A have intestinal hyperpermeability compared with WT mice (12, 23, 25, 36). This evidence concerns the gene F11R and Sepsis.