Among patients with suspected sepsis at the time of enrollment (cohort A plus the crossover cohort on day of suspected sepsis), IMX-BVN-3 had a greater AUROC (0.80 [95% CI, 0.62-0.97]) than either procalcitonin (AUROC, 0.64 [95% CI, 0.37-0.91]; P = .38) or IL-6 (AUROC, 0.58 [95% CI, 0.37-0.80]; P = .08) levels for the detection of bacterial infection but did not reach statistical significance (eFigure 1B in the Supplement). This evidence concerns the gene IL6 and bacterial infectious disease.