IL6 and Sepsis: Among patients with suspected sepsis (cohort A and crossover cohort), IMX-SEV-3 severity scores had an AUROC of 0.74 (95% CI, 0.52-0.96), which was significantly greater than that for procalcitonin (0.42 [95% CI, 0.20-0.64]; P = .01) and IL-6 levels (0.49 [95% CI, 0.25-0.73]; P = .01) and equivalent to the performance of the maximum 24-hour SOFA score (0.74 [95% CI, 054-0.95]) (eFigure 2B in the Supplement).