Here, we identified in a HD mice model, hypermethylation in several transcripts of genes previously described to be altered in HD such as, Pde10a [80, 81], Eif3b [82], Kalrn [47], Ntrk2 [83], Grin2b [84, 85], Dyrk1a [86] and Htt itself. The gene discussed is DYRK1A; the disease is Huntington disease.