At both stages, we identified changes in the levels of m6A in different genes linked to HD, such as Pde10a and Eif3b (at 5 months), Kalrn, Ntrk2, Gnaq, Grin2b, Dyrk1a (at 8 months) and Htt itself (at 5 and 8 months), thus strengthening our hypothesis that altered m6A methylation plays a role in HD pathology (Tables 1 and 2). Here, DYRK1A is linked to Huntington disease.