LGALS3 and differentiated thyroid carcinoma: Immunohistochemistry for papillary thyroid carcinoma markers such as HBME-1, cytokeratin 19, Galectin-3 (all overexpressed in papillary thyroid carcinoma), and CD56 (lost in conventional papillary thyroid carcinoma) [11] may be helpful, but results are often inconsistent since there may be partial HBME-1, cytokeratin 19, Galectin-3 expression, and partial CD56 loss (Fig. 5E, F).