Furthermore, a mutagenic process affecting BRAF exon 15 is suggested by the occurrence of BRAF non p.V600E mutations of little oncogenic potential in the non-neoplastic thyroid surrounding BRAF p.V600E mutated papillary thyroid carcinomas, sometimes in foci of follicular cell atypia, and in the absence of lymphocytic thyroiditis [21]. This evidence concerns the gene BRAF and Hashimoto thyroiditis.