The upregulation of HOTTIP/HOXA9 enhances the Wnt/β-catenin signaling pathway, whereas silencing of HOTTIP/HOXA9 reduces the expression of the Wnt protein family (Wnt1, Wnt3a, Wnt10a, and Wnt110b) in pancreatic cancer [75]. This evidence concerns the gene HOXA9 and familial pancreatic carcinoma.