Lnc00462 promotes the progression of pancreatic cancer through the molecular mechanism of ceRNA and serves as a molecular sponge for miR-665 to upregulate TGF-βRI and TGF-βRII and activate the Smad2/3 signaling pathway to enhance the invasive ability of pancreatic cancer [65]. Here, SMAD2 is linked to familial pancreatic carcinoma.