LncRNA H19 is significantly upregulated in pancreatic cancer cell lines and facilitates pancreatic cancer metastasis and EMT by directly targeting miR-675-3p, which binds to SOCS5, a member of the SOCS protein family that negatively regulates JAK2/STAT3 signaling (Fig. 2) [84]. This evidence concerns the gene CISH and familial pancreatic carcinoma.