MAPT and early-onset autosomal dominant Alzheimer disease: However, in several other genetic variants of dominantly inherited prion protein amyloidosis, intraneuronal Tau inclusions, identical to neurofibrillary tangles (NFTs) in Alzheimer disease (AD), are consistently found to coexist with APrP in the gray matter of the cerebral hemispheres and brainstem, but not in that of the cerebellum [12, 14, 18].