PRNP and neurodegenerative disease: Among hereditary neurodegenerative diseases, the dominantly inherited prion protein (PrP) cerebral amyloidoses include Gerstmann–Sträussler–Scheinker disease (GSS), PrP cerebral amyloid angiopathy, and prion amyloidosis with variable phenotypes; that are caused, respectively, by missense, nonsense, or insertional mutations in the prion protein gene (PRNP) [14].