BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Children show more frequent breakpoints in Alu repeat regions, and unlike adults with CML who have enrichment of fusion sites in the centromeric region, children show enrichment in fusion sites within telomeres overlapping with an Alu repeat region, similar to what is seen in adult Philadelphia-positive acute lymphoblastic leukemia with M-BCR rearrangement [4].