The t(1;22)(p13.3;q13.1); RBM15::MKL1 is the only recurrent cytogenetic abnormality in AMKL classified by the WHO as a separate entity, but the other recurrent cytogenetic aberrations in non-Down syndrome AMKL are also of prognostic importance and therefore deserve further investigation. The gene discussed is RBM15; the disease is Down syndrome.