SMYD3 and small cell lung carcinoma: Consistent with our observations in human SCLC, we noted significant elevation of SMYD3 expression in tumors from the TKO model—as well as in tumor samples from a second SCLC mouse model [ref. 40; RbLoxP/LoxP;Trp53LoxP/LoxP;H11LSL-MycT58A (RPM)]—compared with normal lung tissue (Supplementary Fig. S7B and S7C).