CP and small cell lung carcinoma: Specifically, isolation of endogenously ubiquitinated proteins using tandem ubiquitin-binding element (TUBE) beads to isolate endogenously ubiquitinated proteins from three different SCLC cell lines (DMS-114, H69, and H1048) showed increased RNF113A autoubiquitination during MMS (Fig. 5A) or 4H-CP (Supplementary Fig. S5C) alkylation stress.