Numerous other brain disorders are thought to be exacerbated by an imbalance in S-palmitoylation, such as decreased S-palmitoylation of HTT in Huntington’s disease (Virlogeux et al., 2021; Yanai et al., 2006), increased S-palmitoylation of APP and TAU in Alzheimer’s disease (Cho and Park, 2016), and reduced S-palmitoylation of 5-HTA receptor in major depressive disorder (Gorinski et al., 2019). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.