Neuronal hyperexcitability is coincident with establishment of an epileptic network, and about half of all individuals with KCNMA1 channelopathy, including those with N999S, D434G, and H444Q variants, report a history of seizures or epilepsy (Bailey et al., 2019; Miller et al., 2021). The gene discussed is KCNMA1; the disease is channelopathy.