Moreover, our data for N999S and D434G corroborate mounting evidence, both in patients (Du et al., 2005; Keros et al., 2022; Miller et al., 2021; Zhang et al., 2020) and in animal models (Dong et al., 2021; Kratschmer et al., 2021), that PNKD can be considered the most consistent symptom for KCNMA1 GOF channelopathy. This evidence concerns the gene KCNMA1 and channelopathy.