Changes in BK channel function and/or KCNMA1 expression are associated with a growing number of neurodevelopmental disorders including epilepsy, dyskinesia, autism, Angelman’s syndrome, Fragile X syndrome, and brain and skeletal malformations (Cheng et al., 2021; Deng and Klyachko, 2016; Du et al., 2020; Kessi et al., 2020; Kshatri et al., 2020; Laumonnier et al., 2006; Liang et al., 2019; Miller et al., 2021; N’Gouemo, 2014; Sun et al., 2019a; Sun et al., 2019b). This evidence concerns the gene KCNMA1 and Angelman syndrome.