For example, Ca2+ channelopathy, Prrt2-deficient, and Pnkd mutant mice are characterized by dystonia, chorea, and tonic-clonic episodes (Fureman et al., 2002; Lee et al., 2012; Michetti et al., 2017; Tan et al., 2018; Pan et al., 2020). This evidence concerns the gene PNKD and choreatic disease.