KCNMA1 and Ataxia: At present, there are no patients with homozygous KCNMA1 alleles validated as functionally null for channel activity (Miller et al., 2021), but the ataxia, tremor, decreased strength, and hyperactivity in Kcnma1‒/‒ mice (Imlach et al., 2008; Meredith et al., 2004; Meredith et al., 2006; Sausbier et al., 2004; Typlt et al., 2013; Wang et al., 2020) are symptoms observed at lower incidence among patients.