Increasing studies demonstrated that ferroptosis support the MI pathological process, for example, inhibiting ferroptosis by human umbilical cord blood-derived MSCs exosome could attenuate myocardial injury in acute MI mice (Song et al., 2021); downregulation of GPX4 triggered ferroptosis in cardiomyocytes which contributed to MI (Park et al., 2019); the ferroptosis occurred in acute MI and regulated by Egr-1/miR-15a-5p/GPX4 axis (Fan et al., 2021); treatment with Ferrostatin-1, an iron death inhibitor, reduced infarct size and myocardial injury (Fang et al., 2019). Here, GPX4 is linked to myocardial infarction.