Yu et al. revealed that circ_0003258 could drive prostate cancer metastasis via both a competing endogenous RNA (ceRNA) mechanism of circ_0003258/miR-653-5p/ARHGAP5 and a RBP-involved mechanism of circ_0003258/IGF2BP3 (RBP)/HDAC4 [58]. Here, ARHGAP5 is linked to Familial prostate cancer.