Univariate Cox regression analysis showed that EXTL3 (HR = 0.201, 95%CI = 0.051–0.789, P = 0.021) and PSA value (HR = 1.214, 95%CI = 1.031–1.429, P = 0.020) were both prognostic factors in PCa from TCGA. This evidence concerns the gene KLK3 and posterior cortical atrophy.