However, high concentrations of some proteins involved in inflammation, such as interleukin-6 (IL-6) and interleukin-8 (IL-8), or in angiogenesis, such as angiopoietin-like proteins, have been shown to be associated with a high risk of metastatic progression of breast cancer [27–29]. The gene discussed is CXCL8; the disease is breast carcinoma.