The increased tracer accumulation as imaging correspondent to amyloid deposition in the adipose tissue may be also associated to amyloid deposition in the peripheral nerve running in the same region, damaging the nerves by several known mechanisms, such as mechanical compression, angiopathy with direct blood vessel invasion, enhanced leakage of circulating TTR, and toxicity of nonfibrillar TTR.41,42 Amyloid accumulations in ST, particularly in subcutaneous adipose tissue, may also increase over time and therefore simply reflect a more advanced stage of disease. This evidence concerns the gene TTR and amyloidosis.