The topography of newly identified ADRP does significantly, but moderately, correlate (r = 0.51, p < 0.0001) with previously identified ADRP12, which may be caused by lack of biomarker confirmed diagnoses of AD patients in previous study, but also other factors such as different scanners or the usage of different reconstruction algorithms may have had an effect on pattern topography49. Here, PLIN2 is linked to Alzheimer disease.