It is odd for GBM to be immunosuppressive and have a “cold” TME, since GBM frequently carries cytoplasmic and extrachromosomal DNA, which normally should trigger the cGAS–STING signaling pathway.1 By demonstrating the epigenetic silencing of STING in GBM cells and the immune reactivation by DNMTi decitabine, this study by Low et al. certainly inspires for new combinatorial therapeutic strategies. This evidence concerns the gene CGAS and glioblastoma.