ICAM1 and Stroke: Ischemia/reperfusion (I/R) injury is correlated to vascular inflammation.292 SPIONs-based imaging not only exhibited superior temporal resolution but also had an excellent capability to detect perfusion deficits in the ischemic murine brain.293 Additionally, ECs are critical to post-stroke inflammation, where they modulate diapedesis of leukocytes from the blood to the brain by expressing adhesion molecules, such as VCAM-1, ICAM-1, and P-selectin.