Rolim et al. developed an AuNPs-containing geno-sensor for the detection of SAH polymorphisms in intron 16 of the ACE gene.226 Cortisol and renin are hypertension biomarkers.227,228 A portable chemiluminescence-based lateral flow assay platform was synthesized by conjugating AuNPs with the anti-cortisol and anti-horseradish peroxidase antibodies, which can be used for serum cortisol detection.229 Besides, Long et al. employed a Cy5-labeled and streptavidin-coated QD probes to detect plasma renin activities, which are tightly associated with hypertension and congestive heart failure.228. The gene discussed is REN; the disease is congestive heart failure.