VHL and neoplasm: Among the CRBN-based PROTACs, compound DP-C-1(2, Figure 6) displayed the best dual degradation profile, which was superiorto that induced by the corresponding mono-PROTACs at the same concentration.Similarly, DP-V-4 (3, Figure 6) belonging to the VHL-based series, showedthe best degradation effect, but a weaker anti-proliferative activityin tumor cells compared to the parent inhibitors.