STAT3 and hepatocellular carcinoma: In prostate cancer, FABP5 activates the NF-κB signaling pathway by increasing reactive oxygen species (ROS) and protein kinase C production and induces inflammation and the production of IL-6 and IL-8.16 FABP5 can promote angiogenesis in HCC by activating the IL6/STAT3/VEGFA pathway.17 However, the specific molecular mechanism by which FABP5 regulates the proliferation and migration of hepatoma cells has not been clearly defined, and it needs to be further elucidated.