PI3K/AKT pathway activation by extracellular signals has been observed in HCC and contributes to tumorigenesis.46 Intriguingly, LV et al. found that FABP5 regulated the proliferation of clear cell renal cell carcinoma via the PI3K/AKT signaling pathway.47 In the present study, FABP5 silencing significantly decreased the expression of PI3K, p-AKT, and p-mTOR. This evidence concerns the gene MTOR and hepatocellular carcinoma.