PSMB5 and Splenomegaly: In C57BL/6J-psmb5+/- mice experimentally infected with Henzerling phase I strain, more severe splenomegaly and hepatomegaly were observed (Fig 8D), and the spleen-to-weight ratio and liver-to-weight ratio of psmb5+/- mice were significantly higher than those of the WT mice (Fig 8E and 8F).