The main function of CD39 and CD73 is to convert ATP to AMP and subsequently into adenosine to limit excess immune responses; however, cancer cells take advantage of this mechanism to prevent immune attack and promote tumor growth Wang and Matosevic, 2018; Chambers and Matosevic, 2019; Allard et al., 2017. The gene discussed is ENTPD1; the disease is neoplasm.