Prior evidence also supports this approach, as a CD73 blockade Antonioli et al., 2016; Geoghegan et al., 2016 was shown to result in tumor inhibition from recruitment of NK cells Wang et al., 2018, and an increase in the presence of IFN-γ and perforin Young et al., 2016; Häusler et al., 2014. This evidence concerns the gene PRF1 and neoplasm.