In this hypoxic environment, high levels of ATP are released from the cancer cells that are then consecutively degraded through ecotoenzymes CD39 and CD73 to become adenosine (ADO) Wang and Matosevic, 2018; Poth et al., 2013; Leone and Emens, 2018; Antonioli et al., 2016. Here, ENTPD1 is linked to cancer.