Leucine-rich repeat kinase 2 (LRRK2) is a protein that is primarily linked with PD based on rare coding mutations that segregate in autosomal dominant families (e.g., G2019S, N1437D), coding variants identified through case/control analysis (e.g., G2385R), and common (noncoding) variation associated with clinically diagnosed PD identified in large genome-wide association studies [2]. The gene discussed is LRRK2; the disease is Parkinson disease.