A systematic study of 1039 pathologically confirmed PSP cases and 145 cases of corticobasal degeneration (CBD), which is also classified as a tauopathy, identified two recognized pathogenic LRRK2 mutations (G2019S and R1441C), and two mutations that were predicted to be pathogenic (A1413T and R1707K). The gene discussed is LRRK2; the disease is supranuclear palsy, progressive, 1.