MAPT and tauopathy: The Mayo case series reported a G2019S case with typical PSP features, with tufted astrocytes and involvement of the subthalamic nucleus and globus pallidus, whereas an earlier detailed report of the Canadian family SK reported a 4-repeat predominant tauopathy in a G2019S patient but with a different tau distribution to PSP without involvement of the globus pallidus or subthalamic nucleus [15].