BRAF and melanoma: We were also intrigued by previous reports of differential transformation susceptibility of scale and interscale IFE cells: oncogenic hedgehog signaling causes basal cell carcinoma predominantly in interscale IFE (Sánchez-Danés et al., 2016), whereas oncogenic Braf-induced melanomas arise from pigmented MCs in scale IFE (Köhler et al., 2017).