9-ING-41 downregulates NF-κB and its target genes cyclin D1, Bcl-2, anti-apoptotic protein (XIAP) and B-cell lymphoma-extra large (Bcl-XL) leading to inhibition of tumorigenesis.24 9-ING-41 enhanced apoptosis of aggressive B-cell lymphoma lines through downregulation of anti-apoptotic mechanisms. This evidence concerns the gene NFKB1 and B-cell non-Hodgkin lymphoma.