However, it has been reported that in CHC, type I IFN could enhance the secretion of mast cell-derived HLA-G, which was associated with liver fibrosis [51,52], indicating that type I IFN may promote HCV-related liver fibrosis, which seems contrary to the current evidence that IFN acts against liver fibrosis [53]. Here, HLA-G is linked to cryohydrocytosis.