EGFR is a transmembrane tyrosine kinase receptor that belongs in the ErbB cell membrane receptor family.84 The EGFR signalling cascade is one of the most important pathways responsible for regulation of cell proliferation, angiogenesis, migration, and inhibition of apoptosis.84,85 It regulates key cellular events that drive the progression of not only CRC, but other neoplasms, including lung, pancreatic, breast cancer, etc.86–88. This evidence concerns the gene EGFR and colorectal carcinoma.